Abstract: The aim of the study was to determine the diagnostic value of FNAC in the diagnosis of solid solitary thyroid nodules. This was cross sectional comparative study between pre-operative FNAC and post operative HPE. This study was performed at the department of pathology, MGM Medical College, Jamshedpur on 164 cases with solid solitary thyroid nodule. This study included 164 cases consisting of 114 (69.51%) female and 50 (30.48%) male with female and male ratio of 2.3:1. The maximum patients with solid solitary nodules were in the age group 31-40 years most of the patients presented in the 3rd and 4th decade of life. In this study, the diagnostic results of FNAC was accuracy 82.92%, sensitivity 88.09%, specificity 77.50%, PPV 80.43%. The study highlights that FNAC is a sensitive and specific diagnostic test for thyroid nodules but this is not a substitute for HPE.     

Abstract: In present research, a series of 2{[2-(4-chlorophenyl)-4- oxoquinazolin-3(4H)-yl]amino}-N-(substitutedphenyl) acetamides were taken from literature survey. The molecular docking study was performed on the selected quinazolinone derivatives into four different cancer inhibitory proteins. All the compounds showed average binding towards 2W1C and 2WD3 proteins whereas very promising interaction towards 4CQ0 and 3HB5 proteins. The compound RS_1, 2 and 7 were found to be potent inhibitor as they showed good binding against carbonic anhydrase inhibitors (4CQ0) and hydroxysteroid dehydrogenase inhibitor (3HB5) and also interacting with the active site of amino acids present within the binding cavity.