Abstract: The assessment of the degree of liver stiffness is important in the treatment of liver diseases. The various types of ultrasound elastography are relatively well studied. Transient elastography (TE) is a proven method of assessment of liver stiffness and possesses the properties of a prognostic indicator. In contrast to this method, the significance of strain elastography used to assess the degree of liver stiffness remains insufficiently established.
Methods. RTE elastography was conducted in 246 patients. 34 of them were with chronic viral Hepatitis C, 80 with chronic viral Hepatitis B, 30 with nonalcoholic liver disease, 30 with alcoholic liver disease, 42 with hepatic cirrhosis and there was a control group of 30 healthy individuals. The biomarkers APRI, Fibroindex, Forn’s index, FIB-4, Fibrotest were examined. In all patients without the control group a liver biopsy was performed for histological evaluation of fibrosis. The RT-generated elastographic imaging was subjected to qualitative analysis by a specially developed program and the derived Liver Fibrosis Index (LFI) was compared to histological and laboratory data.
Results. The value of LFI increases as fibrosis progresses. LFI is significantly different in the cases of moderate fibrosis (F0-2) and advanced fibrosis (F3, 4). LFI shows a good correlation in determining advanced fibrosis and good reproducibility of the results. LFI was found to be an independent prognostic factor in patients with chronic liver disease.
Conclusion. Strain elastography can be used to determine advanced liver fibrosis without influence of hepatic inflammation, unlike other serology markers of liver fibrosis. RTE is probably a prognostic factor in chronic liver diseases..